Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lasofoxifene Tartrate (CP-336156) 是一种非甾体类的雌激素受体选择性调节剂 (SERM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 500 | 现货 | ||
10 mg | ¥ 750 | 现货 | ||
25 mg | ¥ 1,350 | 现货 | ||
50 mg | ¥ 2,500 | 现货 | ||
100 mg | ¥ 4,000 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 566 | 现货 |
产品描述 | Lasofoxifene Tartrate (CP-336156) is a third-generation, non-steroidal selective estrogen receptor modulator. |
体内活性 | Lasofoxifene (LAS) and BZA reduced the clinical severity of arthritis as well as the grade of histologic synovitis and erosions on cartilage and bone.?Moreover, SERMs protected against generalised bone loss in CIA by increasing trabecular BMD.?Both SERMs decreased serum marker of cartilage destruction and LAS reduced serum IL-6 levels.?SERMs did not alter Th17 cells in lymph nodes as E2 did[1]. |
动物实验 | Female DBA/1 mice were ovariectomised and subjected to CIA as a model of post-menopausal RA. Mice received treatment with Lasofoxifene (LAS), BZA, 17β-estradiol (E2) as reference or vehicle. Arthritis development was assessed and BMD was determined by peripheral quantitative CT of the femurs. Serologic markers of inflammation and cartilage destruction were analysed. Immune cells in lymph nodes were studied by flow cytometry[1]. |
别名 | CP-336156, 酒石酸拉索昔芬 |
分子量 | 563.64 |
分子式 | C32H37NO8 |
CAS No. | 190791-29-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (10.65 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7742 mL | 8.8709 mL | 17.7418 mL | 44.3546 mL |
5 mM | 0.3548 mL | 1.7742 mL | 3.5484 mL | 8.8709 mL | |
10 mM | 0.1774 mL | 0.8871 mL | 1.7742 mL | 4.4355 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lasofoxifene Tartrate 190791-29-8 Endocrinology/Hormones Estrogen Receptor/ERR osteoporosis inhibit CP-336156 酒石酸拉索昔芬 arthritis endocrine resistant breast cancer CP 336156 Inhibitor selective oestrogen receptor modulators tartrate oestrogen CP336156 Lasofoxifene inhibitor